2-Amino-2-methyl-1,3-propanediol → HCID 22457909, compound

Participants

Reaction Steps

A solution of 500 mg of 2,5-dimethoxycarbonylpyrazine and 525 mg of 2-amino-2-methyl-1,3-propanediol in 3 cm3 of ethanol is heated at a temperature in the region of the reflux temperature for 90 minutes. The reaction mixture is filtered while hot. The white solid is washed with 5 cm3 of boiling ethanol. 200 mg of N,N′-bis(1,3-dihydroxy-2-methyl-2-propyl)pyrazine-2,5-dicarboxamide are thus obtained in the form of a white solid melting at 208° C. [1H NMR spectrum (400 MHz, CDCl3, δ at ppm): 1.34 (s, 6H: 2×CH3); 3.55 and 3.66 (2 dd, J=11 and 5.5 Hz, 8H: 4×OCH2); 5.01 (t, J=5.5 Hz, 4H: 4×OH); 8.22 (s, 2H: ═CH at 3 and ═CH at 6); 9.20 (s, 2H: 2×CONH)].

Provenance & Evidence