2-Amino-2-methyl-1,3-propanediol → HCID 22458023, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 500 mg of 2,6-dimethoxycarbonylpyrazine and 525 mg of 2-amino-2-methyl-1,3-propanediol in 5 cm3 of ethanol is heated at a temperature in the region of the reflux temperature for 3 hours. The reaction mixture is cooled to a temperature of 20° C. and the white solid formed is then filtered off and washed with twice 5 cm3 of ethanol. 260 mg of N,N′-bis(1,3-dihydroxy-2-methyl-2-propyl)pyrazine-2,6-dicarboxamide are thus obtained in the form of a white solid melting at 169° C. [1H NMR spectrum (400 MHz, (CD3)2SO-d6, δ in ppm): 1.34 (s, 6H: 2×CH3); 3.61 and 3.69 (2 dd, J=11 and 5.5 Hz, 8H: 4×CH2O); 4.88 (t, J=5.5 Hz, 4H: 4×OH); 8.16 (s, 2H: 2×CONH); 9.35 (s, 2H: ═CH at 3 and ═CH at 5)].

Provenance & Evidence