Dimethylformamide dimethyl acetal → N-[3-(3-Dimethylaminoacryloyl)phenyl]acetamide

Participants

Reaction Steps

A mixture of 3-acetamidoacetophenone (30 g, 169 mmol) and dimethylformamide dimethyl acetal (50 mL, 376 mmol) is refluxed under nitrogen for 8 hours. The reaction mixture is cooled and the solid collected by filtration to yield product (5) as an orange solid (37.2 g, 160 mmol, 95%).

Provenance & Evidence