HCID 18399709, compound → HCID 18399757, compound

Participants

Reaction Steps

A solution of 0.57 g of the product obtained in Step F in 4 ml of HCl (5N) is heated at reflux for 12 hours and then cooled, washed with ether, rendered basic by the addition of 20% sodium hydroxide solution and extracted with dichloromethane. Drying, filtration and concentration of the organic phase under reduced pressure, followed by chromatography on silica gel (CH2Cl2/MeOH/NH4OH: 90/10/1), enables the expected product to be isolated.

Provenance & Evidence