Toluene → 1-[N-(2-trifluoromethylphenyl)-N-cyclohexylcarbonyl-2-aminoethyl]-4-(2-methoxyphenyl)piperazine

Participants

Reaction Conditions

Reaction Steps

A mixture of N-(2-trifluoromethylphenyl)cyclohexanecarboxamide (0.2 g) (Compd 26A), 1-(2-chloroethyl)-4-(2-methoxyphenyl)piperazine (0.37 g),50% (w/w) NaOH (0.5 mL), TEBAC (0.16 g) and toluene (2 mL) was stirred at 80° C. for 3.5 h. An additional amount of compd 26A (0.2 g) was then added and after 6 h stirring at 80° C. the mixture was poured into H2O and extracted with CH2Cl2. The organic phase was dried on anhydrous Na2SO4, evaporated to dryness and the residue purified by flash chromatography (EtOAc-petroleum ether 3:7) giving 0.12 g (17%) of the title compound.

Provenance & Evidence