HCID 9847377, compound → HCID 22458162, compound

HRID 2184841Notes

Reaction equation

HRID 2184841 reaction equation
[CH:1]1([C:7]([N:9]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[O:35][C:36]([F:39])([F:38])[F:37])[CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][N:15]([C:18]3[CH:23]=[CH:22][C:21]([N+:24]([O-])=O)=[CH:20][C:19]=3[O:27][CH3:28])[CH2:14][CH2:13]2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[N+](C1C=CC=CC=1N(C(C1CCCCC1)=O)CCN1CCN(C2C=CC=CC=2OC)CC1)([O-])=O>>[CH:1]1([C:7]([N:9]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[O:35][C:36]([F:38])([F:39])[F:37])[CH2:10][CH2:11][N:12]2[CH2:13][CH2:14][N:15]([C:18]3[CH:23]=[CH:22][C:21]([NH2:24])=[CH:20][C:19]=3[O:27][CH3:28])[CH2:16][CH2:17]2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 9847377HCID 9847377, compoundHCID 22458129HCID 22458129, compound

Product 1

HCID 22458162HCID 22458162, compoundYield 58%

Procedure

The title compound was prepared according to the procedure reported in example 27, but substituting the compound of example 55 for the compound of example 2 and heating at reflux for 3 h. The residue was purified by flash chromatography (EtOAc). Yield: 58%.

Workup

  1. temperatureheating
  2. temperatureat reflux for 3 h
  3. customThe residue was purified by flash chromatography (EtOAc)

Sources & evidence

ORD record
ord-5f670e3fd09947a4994cd44a3d59c01b
Source dataset
uspto-grants-2002_06
Patent number
US06399614B1

Reaction notes

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