HRID2184841

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccccc1N1CCN(CCN(C(=O)C2CCCCC2)c2ccccc2[N+](=O)[O-])CC1

HCID9847377

未命名化合物

结构：COc1cc([N+](=O)[O-])ccc1N1CCN(CCN(C(=O)C2CCCCC2)c2ccccc2OC(F)(F)F)CC1

HCID22458129

未命名化合物

PRODUCTS

生成物

结构：COc1cc(N)ccc1N1CCN(CCN(C(=O)C2CCCCC2)c2ccccc2OC(F)(F)F)CC1

HCID22458162

未命名化合物

收率 58%

PROCEDURE

实验过程

The title compound was prepared according to the procedure reported in example 27, but substituting the compound of example 55 for the compound of example 2 and heating at reflux for 3 h. The residue was purified by flash chromatography (EtOAc). Yield: 58%.

WORKUP

后处理

temperatureheating
temperatureat reflux for 3 h
customThe residue was purified by flash chromatography (EtOAc)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5f670e3fd09947a4994cd44a3d59c01b
来源数据集: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06399614B1
来源说明: uspto-grants-2002_06

反应 SMILES

[CH:1]1([C:7]([N:9]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[O:35][C:36]([F:39])([F:38])[F:37])[CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][N:15]([C:18]3[CH:23]=[CH:22][C:21]([N+:24]([O-])=O)=[CH:20][C:19]=3[O:27][CH3:28])[CH2:14][CH2:13]2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[N+](C1C=CC=CC=1N(C(C1CCCCC1)=O)CCN1CCN(C2C=CC=CC=2OC)CC1)([O-])=O>>[CH:1]1([C:7]([N:9]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[O:35][C:36]([F:38])([F:39])[F:37])[CH2:10][CH2:11][N:12]2[CH2:13][CH2:14][N:15]([C:18]3[CH:23]=[CH:22][C:21]([NH2:24])=[CH:20][C:19]=3[O:27][CH3:28])[CH2:16][CH2:17]2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1