HRID2184842

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccccc1N1CCN(CCN(C(=O)C2CCCCC2)c2ccccc2N)CC1

HCID18782313

未命名化合物

结构：COc1cc(N)ccc1N1CCN(CCN(C(=O)C2CCCCC2)c2ccccc2OC(F)(F)F)CC1

HCID22458162

未命名化合物

PRODUCTS

生成物

结构：COc1cc(NC(C)=O)ccc1N1CCN(CCN(C(=O)C2CCCCC2)c2ccccc2OC(F)(F)F)CC1

HCID22458120

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized according to the procedure reported in example 28 but substituting the compound of example 56 for the compound of example 27 and stirring for 20 h. The residue was purified by flash chromatography (CHCl3-2 N methanolic NH3 100:3) affording the title compound as a vitreous pink solid. Yield: 77%.

WORKUP

后处理

customThe title compound was synthesized
customThe residue was purified by flash chromatography (CHCl3-2 N methanolic NH3 100:3)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9223298adfc342b08f04aaaec7b792ac
来源数据集: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06399614B1
来源说明: uspto-grants-2002_06

反应 SMILES

[CH:1]1([C:7]([N:9]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[O:33][C:34]([F:37])([F:36])[F:35])[CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][N:15]([C:18]3[CH:23]=[CH:22][C:21]([NH2:24])=[CH:20][C:19]=3[O:25][CH3:26])[CH2:14][CH2:13]2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.NC1C=CC=CC=1N(C(C1CCCCC1)=O)CCN1CCN([C:54]2C=CC=C[C:55]=2[O:60]C)CC1>>[CH:1]1([C:7]([N:9]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[O:33][C:34]([F:36])([F:37])[F:35])[CH2:10][CH2:11][N:12]2[CH2:13][CH2:14][N:15]([C:18]3[CH:23]=[CH:22][C:21]([NH:24][C:55](=[O:60])[CH3:54])=[CH:20][C:19]=3[O:25][CH3:26])[CH2:16][CH2:17]2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1