1-(2-Trifluoromethoxyphenyl)piperazine → HCID 22458150, compound

HRID 2184845Notes

Reaction equation

HRID 2184845 reaction equation
[F:1][C:2]([F:17])([F:16])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>CCOCC>[F:1][C:2]([F:16])([F:17])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][N:10]([C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[O:3][C:2]([F:1])([F:16])[F:17])[CH2:11][CH2:12]1

Participants

3

Reactant 1

HCID 107529251-(2-Trifluoromethoxyphenyl)piperazine

Product 1

HCID 22458150HCID 22458150, compoundYield 41%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
120 °C

Procedure

The title compound was obtained following the procedure described for example 54, but using 1-(2-trifluoromethoxyphenyl)piperazine in place of 1-(4-nitro-2-methoxyphenyl)piperazine. The reaction mixture was heated at 120° C. for 8 h. The residue obtained by usual work-up and extraction with Et2O was purified by flash chromatography (petroleum ether-EtOAc gradient from 90:10 to 80:20) to afford the title compound. Yield: 41%.

Workup

  1. customwas purified by flash chromatography (petroleum ether-EtOAc gradient from 90:10 to 80:20)

Sources & evidence

ORD record
ord-bb4173f860024e33ac2c23ea77378532
Source dataset
uspto-grants-2002_06
Patent number
US06399614B1

Reaction notes

Loading…