HCID 22458129, compound → HCID 11628605, compound

HRID 2184846Notes

Reaction equation

[CH:1]1([C:7](N(C2C=CC=CC=2OC(F)(F)F)CCN2CCN(C3C=CC([N+]([O-])=O)=CC=3OC)CC2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[F:40][C:41]([F:69])([F:68])[O:42][C:43]1[CH:48]=[CH:47][CH:46]=[CH:45][C:44]=1[NH:49][CH2:50][CH2:51][N:52]1[CH2:57][CH2:56][N:55]([CH2:58][C:59]2[CH:64]=[C:63]([O:65][CH3:66])[CH:62]=[CH:61][C:60]=2[Br:67])[CH2:54][CH2:53]1>>[CH:1]1([C:7]([N:49]([C:44]2[CH:45]=[CH:46][CH:47]=[CH:48][C:43]=2[O:42][C:41]([F:40])([F:68])[F:69])[CH2:50][CH2:51][N:52]2[CH2:57][CH2:56][N:55]([CH2:58][C:59]3[CH:64]=[C:63]([O:65][CH3:66])[CH:62]=[CH:61][C:60]=3[Br:67])[CH2:54][CH2:53]2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

Reactant 2

HCID 22458129HCID 22458129, compound

HCID 22458180HCID 22458180, compound

Product 1

HCID 11628605HCID 11628605, compoundYield 67%

Procedure

The title compound was prepared following the procedure described for the compound of example 55, substituting the compound of example 74 for the compound of example 54. The residue was purified by flash chromatography (CHCl3-2 N methanolic NH3 100:1). Yield: 67%.

Workup

customThe residue was purified by flash chromatography (CHCl3-2 N methanolic NH3 100:1)

Sources & evidence

ORD record: ord-3b7c6cebbaee4174ae7c77b9ec424081
Source dataset: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06399614B1

Reaction notes

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