HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl pyruvate → N-(3,4Difluorophenyl)alanine Ethyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl pyruvate | HCID 12041 | — |
| Reactant | 3,4-Difluoroaniline | HCID 77469 | — |
| Product | N-(3,4Difluorophenyl)alanine Ethyl Ester | HCID 15434838 | — |
Reaction Steps
Following General Procedure A above and using 3,4-difluoroaniline (Aldrich) and ethyl pyruvate (Aldrich), the title compound was prepared. The reaction was monitored by tlc on silica gel (Rf=0.4 in 25% EtOAc/hexanes) and purification was by preparative plate chromatography (silica gel using 25% EtOAc/hexanes as the eluant).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06399628B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-4388e81f4c914e34a4a32d2499b17920 |
| Source note | uspto-grants-2002_06 |