Potassium Phosphate, Tribasic → HCID 86758107, compound

Participants

Reaction Steps

To a solution of ethyl (Z)-3-{[(trifluoromethyl)sulfonyl]-oxy}-2-propenoate (330 mg, 1.25 mmol) in 5 ml anhydrous dioxane was added potassium phosphate (398 mg, 1.88 mmol), 3-cyanophenyl boronic acid (185 mg, 1.25 mmol), and tetrakis (triphenylphosphine)palladium(0) (36 mg, 0.031 mmol). Reaction mixture was heated to reflux and stirred overnight. Mixture was filtered through a pad of Celite, diluted with 50 ml ethyl acetate, washed with 2×50 ml water, 2×50 ml saturated brine solution, dried over magnesium sulfate, filtered and concentrated in vacuo. Residue was chromatographed on silica gel using 5% EtOAc in hexane as the eluent to give ethyl (Z) 3-(3-cyanophenyl)-2-propenoate (240 mg, 71%) as a clear oil after drying. ES-MS (M+H+): 216.05

Provenance & Evidence