Hexane → HCID 70107072, compound

Participants

Reaction Steps

To a solution of 2′-tert-butylaminosulfonyl-4-amino-[1,1′]-biphenyl (198 mg, 0.65 mmol) in 5 ml anhydrous dichloromethane was added a solution of 2M trimethylaluminum in hexane (0.98 ml, 1.95 mmol). Reaction was stirred at room temperature for 20 minutes to which a solution of ethyl (Z) 3-(3-cyanophenyl)-2-propenoate (140 mg, 0.65 mmol) in 1 ml anhydrous dichloromethane was added. Reaction was stirred at room temperature overnight. Reaction was quenched with 5 ml 1N HCl after which an additional 20 ml dichloromethane was added. Organic was washed with 2×25 ml water, dried over magnesium sulfate and concentrated to give (2Z)-N-[4-(2-{[(tert-butyl)amino]sulfonyl}phenyl)phenyl]-3-(3-cyanophenyl)but-2-enamide (200 mg, 65%) as a light brown residue which was sufficiently pure to be used without further purification.

Provenance & Evidence