Benzylamine → HCID 12043494, Verbindung

HRID 2184936Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2184936
[CH2:1]([N:3]1[C:15]2[CH:14]=[CH:13][C:12]([C:16]([OH:18])=O)=[CH:11][C:10]=2[C:9]2[C:4]1=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH3:2].C1N=CN(C(N2C=NC=C2)=O)C=1.[CH2:31]([NH2:38])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>C(Cl)Cl>[CH2:31]([NH:38][C:16]([C:12]1[CH:13]=[CH:14][C:15]2[N:3]([CH2:1][CH3:2])[C:4]3[C:9]([C:10]=2[CH:11]=1)=[CH:8][CH:7]=[CH:6][CH:5]=3)=[O:18])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1

Komponenten

5

Edukt 3

HCID 7504BenzylamineHCID 682631,1'-CarbonyldiimidazoleHCID 49128699-Ethyl-9H-carbazole-3-carboxylic acid

Produkt 1

HCID 12043494HCID 12043494, VerbindungAusbeute 84 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

To a suspension of 9-Ethyl-9H-carbazole-3-carboxylic acid (75 mg, 0.313 mmol) in CH2Cl2 (1 ml) at room temperature was added CDI (56 mg, 0.344 mmol) ) in CH2Cl2 (1 ml), and after stirring for 30 minutes benzylamine (38 μl, 0. 344 mmol) was added. When the reaction was complete the reaction mixture was directly loaded onto a silica column and eluted with CH2Cl2 to afforded the desired product as a white foam (86 mg, 84% yield). MS m/z @ 329 (m+1).

Aufarbeitung

  1. additionwas added
  2. washeluted with CH2Cl2

Quellen und Nachweise

ORD-Eintrag
ord-282619371f6a47d5bdf44758a6f0055a
Quelldatensatz
uspto-grants-2002_06
Patentnummer
US06399631B1

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