HCID 12049889, compound → HCID 69828661, compound

Participants

Reaction Steps

To a stirred solution of benzyl 2-[3-chloro-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenoxy]-acetate (136 mg) in ethyl acetate (2.0 ml) was added 4N hydrogen chloride ethyl acetate solution (161 μl) under ice-cooling, and the mixture was vigorously stirred for an hour at room temperature. Collection of the resulting precipitates by filtration gave benzyl 2-[3-chloro-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-phenoxy]acetate hydrochloride (137 mg).

Provenance & Evidence