反应详情

A solution of the product from Step A (2.5 g, 7.18 mmol), methyl 3-chloro-4-hyrdoxyphenylacetate (1.42 g, 7.11 mmol) and cesium carbonate (2.43 g, 7.45 mmol) in DMF (20 mL) was stirred at 40° C. overnight. The reaction mixture was partitioned between ethyl acetate and 0.2N HCl. The organic was washed twice with water, then dried over sodium sulfate. The organic was filtered and evaporated to an oil which was chromatographed over silica gel with 10% of ethyl acetate in hexane to afford the title compound.

1. customThe reaction mixture was partitioned between ethyl acetate and 0.2N HCl
2. washThe organic was washed twice with water
3. dry with materialdried over sodium sulfate
4. filtrationThe organic was filtered
5. customevaporated to an oil which
6. customwas chromatographed over silica gel with 10% of ethyl acetate in hexane