Urea → HCID 9912134, compound

Participants

Reaction Steps

A solution of methyl 3-(3-(2-propyl-4-phenoxyphenoxy)-propoxy)mandelate (194 mg), urea (39 mg) and sodium methoxide (0.90 mL, 0.5 M) was refluxed overnight. The reaction mixture was partitioned between ethyl acetate and water. The organic layer was washed twice with water, dried over sodium sulfate, filtered and evaporated to an oil, which was chromatographed over silica gel with 3% of methanol in methylenechloride to afford the title compound.

Provenance & Evidence