Acetic Acid → HCID 53883486, compound

HRID 2185053Notes

Reaction equation

HRID 2185053 reaction equation
[C:1]([CH2:5][C:6](Cl)=[O:7])([CH3:4])([CH3:3])[CH3:2].[N+:9](=[CH2:11])=[N-:10].C(O)(=O)C>C(OCC)C>[N+:9](=[CH:11][C:6](=[O:7])[CH2:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[N-:10]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 9550DiazomethaneHCID 815143,3-Dimethylbutanoyl chloride

Product 1

HCID 53883486HCID 53883486, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

A solution of tert-butyl acetyl chloride (1.136 grams) in dry ethyl ether (10 mL) was slowly added to a 0° C. diethyl ether (20 mL) solution of freshly generated diazomethane (from 20 grams Diazald). After stirring for 30 minutes, the reaction was warmed to ambient temperature for another 30 minutes. Acetic acid (2 mL) was added and the reaction partitioned between methyl tert-butyl ether and water. The organic was washed once with water, dried over magnesium sulfate and filtered. Concentration afforded an oil containing the title compound which was immediately used with no further purification.

Workup

  1. customthe reaction partitioned between methyl tert-butyl ether and water
  2. washThe organic was washed once with water
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationConcentration
  6. customafforded an oil

Sources & evidence

ORD record
ord-4a0ca1cbc3f94b208928dc8faf86303b
Source dataset
uspto-grants-2002_06
Patent number
US06399640B1

Reaction notes

Loading…