2-Propyl-4-pyrazinyloxyphenol → Ethyl 4-(3-(2-propyl-4-pyrazinyloxyphenoxy)-propoxy)mandelate

HRID 2185066Notes

Reaction equation

HRID 2185066 reaction equation
[CH2:1]([C:4]1[CH:9]=[C:8]([O:10][C:11]2[CH:16]=[N:15][CH:14]=[CH:13][N:12]=2)[CH:7]=[CH:6][C:5]=1[OH:17])[CH2:2][CH3:3].Br[CH2:19][CH2:20][CH2:21][O:22][C:23]1[CH:35]=[CH:34][C:26]([CH:27]([OH:33])[C:28]([O:30][CH2:31][CH3:32])=[O:29])=[CH:25][CH:24]=1>>[CH2:1]([C:4]1[CH:9]=[C:8]([O:10][C:11]2[CH:16]=[N:15][CH:14]=[CH:13][N:12]=2)[CH:7]=[CH:6][C:5]=1[O:17][CH2:19][CH2:20][CH2:21][O:22][C:23]1[CH:35]=[CH:34][C:26]([CH:27]([OH:33])[C:28]([O:30][CH2:31][CH3:32])=[O:29])=[CH:25][CH:24]=1)[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 224589672-Propyl-4-pyrazinyloxyphenolHCID 22459007Ethyl 4-(3-bromopropoxy)mandelate

Product 1

HCID 22458969Ethyl 4-(3-(2-propyl-4-pyrazinyloxyphenoxy)-propoxy)mandelate

Procedure

The title compound was prepared according to the method described in Example 22, Step C using 2-propyl-4-pyrazinyloxyphenol (19.0 g, 62.0 mmol) and ethyl 4-(3-bromopropoxy)mandelate (19.5 g, 58.9 mmol) (as prepared in Example 22, Step C) as the starting materials.

Sources & evidence

ORD record
ord-7c620d69eb954939a0c51e19bad40448
Source dataset
uspto-grants-2002_06
Patent number
US06399640B1

Reaction notes

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