Methylamine → HCID 22459686, compound

Participants

Reaction Conditions

Reaction Steps

4-Chloro-N-[3-methoxy-4-(5-oxazolyl)phenyl]-6-phenyl-1,3,5-triazin-2-amine, 103, (27 mg, 0.07 mmol) was suspended in 2M methylamine in THF (1 mL, 2 mmol) was added and the reaction mixture heated in a sealed tube at 80° C. overnight. The product was filtered and purified by flash column chromatography (2% methanol in methylene chloride) to yield 22 mg (83%) of the title compound LCMS (Ret Time=3.15 min, HPLC condition B) M+H+=375.23 (100%).

Provenance & Evidence