HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonic Acid → Ziprasidone mesylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonic Acid | HCID 6395 | — |
| Reactant | Ziprasidone | HCID 60854 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | Ziprasidone mesylate | HCID 154068 | — |
Reaction Steps
1 g of ziprasidone free base was added to 20 mL of isopropyl alcohol, followed by 140 mg of methanesulfonic acid. After a few minutes the slurry which formed thickened and lightened somewhat in color as it precipitated. The salt was harvested by filtration through a 5 μm polytetrafluoroethylene membrane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06399777B2 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-033bf44b26ce437cb4fff9d0008623f5 |
| Source note | uspto-grants-2002_06 |