Tetrahydrofuran → HCID 131722554, compound

Participants

Reaction Conditions

Reaction Steps

1 g of ziprasidone free base was added to 45 mL of THF and 1 mL of water, and the mixture was heated to 60° C. while stirring. The mixture was maintained at 60° C. for two hours, at which time all of the free base had dissolved. 156 mg of ethanesulfonic acid was added and stirring was maintained at 60° C. for two more hours. The mixture turned from light orange to hazy during this time, at which point heating was stopped and the salt started to precipitate. The mixture was allowed to cool to room temperature overnight while stirring continued. The salt was then harvested by filtration as in Example 5.

Provenance & Evidence