HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl formate → 5-Diethylphosphono-2-thiophenecarboxaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl formate | HCID 7865 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | 2-Diethylphosphonothiophene | HCID 4254391 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-Diethylphosphono-2-thiophenecarboxaldehyde | HCID 22274952 | — |
Reaction Steps
A solution 1.0 mmol of diethyl 2-thiophenephosphonate in tetrahydrofuran was treated with 1.12 mmol LDA at −78° C. for 20 min. 1.5 mmol methyl formate was added and the reaction was stirred for 1 hr. Extraction and chromotagraphy gave 5-diethylphosphono-2-thiophenecarboxaldehyde as a clear yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06399782B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-54a92a831e5347908ab4a5296adbe6f5 |
| Source note | uspto-grants-2002_06 |