Pyridine → 2H-1,3-Benzoxazine-2,4(3H)-dione

Temperature

5 °C

Following the method of Shapiro et al., JACS, 79:2811 (1957), salicylamide (59.0 g, 0.43 mol, 1.0 eq), pyridine (150 mL) and acetonitrile (125 mL) were placed in a 500 mL three-neck flask equipped with a magnetic stir bar, a thermometer, and an addition funnel. After cooling to about 5° C. in a salt ice bath, ethyl chloroformate (45.2 mL, 0.47 mol, 1.1 eq) was added dropwise over 25 minutes so that the reaction temperature did not exceed 10° C. during the addition. The reaction mixture was stirred for 30 minutes at 10° C. The addition funnel was replaced with a Dean-Stark trap and a water-cooled condenser. The mixture was heated to a distillation temperature of about 90° C. Distillation was continued until the internal temperature reached about 124° C. (200 ml. of distillate removed). The temperature was reduced so that the reaction mixture refluxed but did not distill. After one hour at reflux, the reaction mixture was cooled to about 25° C. and poured into water (400 mL). Concentrated aqueous hydrochloric acid (24 mL) was added. A white solid formed, which was collected by filtration, washed with water (200 mL), and dried under vacuum. The 2H-1,3-benzoxazine-2,4(3H)-dione was isolated as a white solid (59.3 g, 85% yield).

1. customwere placed in a 500 mL three-neck flask
2. customequipped with a magnetic stir bar
3. additiondid not exceed 10° C. during the addition
4. temperatureThe mixture was heated to a distillation temperature of about 90° C
5. distillationDistillation
6. customreached about 124° C.
7. custom(200 ml. of distillate removed)
8. temperaturerefluxed
9. distillationdid not distill
10. temperatureAfter one hour at reflux
11. temperaturethe reaction mixture was cooled to about 25° C.
12. additionpoured into water (400 mL)
13. additionConcentrated aqueous hydrochloric acid (24 mL) was added
14. customA white solid formed
15. filtrationwhich was collected by filtration
16. washwashed with water (200 mL)
17. customdried under vacuum

ORD record

ord-fa45b6d273914fe59197af595baa9d6e

Source dataset

uspto-grants-2002_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06399798B2