HCID 59586742, compound → HCID 59586756, compound

HRID 218517Notes

Reaction equation

HRID 218517 reaction equation
C(O[CH:5]([C:8]1[C:9]([F:14])=[N:10][CH:11]=[CH:12][CH:13]=1)[CH2:6][CH3:7])(=O)C.[H][H]>C(O)C.[Pd]>[CH2:5]([C:8]1[C:9]([F:14])=[N:10][CH:11]=[CH:12][CH:13]=1)[CH2:6][CH3:7]

Participants

5

Reactant 2

HCID 59586742HCID 59586742, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 59586756HCID 59586756, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

3.50 g (17.7 mmol) of the product from example 49A are dissolved in 30 ml of ethanol and admixed with 2.00 g of 10% palladium on activated carbon. Hydrogenation is effected overnight in a hydrogen atmosphere under standard pressure. The mixture is filtered with suction, washed with ethanol and concentrated cautiously under reduced pressure. This affords 1.9 g of approx. 89% pure product (69% of theory), which is converted further without purification.

Workup

  1. filtrationThe mixture is filtered with suction
  2. washwashed with ethanol
  3. concentrationconcentrated cautiously under reduced pressure
  4. customThis affords 1.9 g of approx. 89% pure product (69% of theory), which is converted further without purification

Sources & evidence

ORD record
ord-95be74c586c74e8ea53d18b7c3ab4a50
Source dataset
uspto-grants-2012_06
Patent number
US08198267B2

Reaction notes

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