Benzenesulfonamide, 4-amino-N,N-dimethyl- → HCID 178486144, compound

HRID 2185181Notes

Reaction equation

HRID 2185181 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[N:19]=[C:18]([OH:20])[C:17]3[C:12](=[C:13]([C:24](O)=[O:25])[CH:14]=[C:15]([N+:21]([O-:23])=[O:22])[CH:16]=3)[N:11]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].[CH3:27][N:28]([CH3:39])[S:29]([C:32]1[CH:38]=[CH:37][C:35]([NH2:36])=[CH:34][CH:33]=1)(=[O:31])=[O:30]>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[N:19]=[C:24]([OH:25])[C:13]3[C:12](=[C:17]([C:18]([NH:36][C:35]4[CH:37]=[CH:38][C:32]([S:29](=[O:31])(=[O:30])[N:28]([CH3:27])[CH3:39])=[CH:33][CH:34]=4)=[O:20])[CH:16]=[C:15]([N+:21]([O-:23])=[O:22])[CH:14]=3)[N:11]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

3

Reactant 2

HCID 74369Benzenesulfonamide, 4-amino-N,N-dimethyl-HCID 178524572HCID 178524572, compound

Product 1

HCID 178486144HCID 178486144, compound

Procedure

The title compound was prepared in a manner analogous to Example 1 from 2-((3,4-dichlorophenyl)amino)-4-hydroxy-6-nitroquinazoline-8-carboxylic acid and 4-(N,N-dimethyl)sulfamoylaniline. 1H NMR (300 MHz, DMSO-d6):. 11.87 (s, 1H), 10.45 (s, 1H), 8.90 (d, J=2.7 Hz, 1H), 8.80 (d, J=2.7 Hz, 1H), 8.01 (d, J=2.4 Hz, 1H), 7.65 (d, J=8.7 Hz, 2H), 7.54 (d, J=8.7 Hz, 2H 2.64 (s, 6H). MS (APCI+): m/z 577, 579.

Sources & evidence

ORD record
ord-893432c5edfa444b8de9a12e2fceb875
Source dataset
uspto-grants-2002_06
Patent number
US06399603B1

Reaction notes

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