3,4-Dichloroaniline → HCID 178526426, compound

Participants

Reaction Steps

A solution of 8-bromo-2-chloro-6-nitroquinazolin-4-ol (2.96 g) and 3,4-dichloroaniline (4.72 g) in 1-methyl-2-pyrrolidinone (70 mL) was heated at 140° C. for 3 h. The mixture was cooled to room temperature and poured onto ice/water (600 mL). The precipitate which formed was filtered, washed with water (50 mL), diethyl ether (150 mL) and dried in vacuo to afford the title compound (4.18 g). 1H NMR (300 MHz, DMSO-d6) δ11.62 (s, 1H), 9.64 (s, 1H), 8.72-8.65 (m, 3H), 7.61 (s, 1H), 7.60 (5, 1H); HPLC (Method B): 10.56 min. MS (APCI−): m/z 429, 431.

Provenance & Evidence