HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 3-(2-Methoxy-4-nitrophenyl)pyridin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-Fluoro-3-(2-methoxy-4-nitrophenyl)pyridine | HCID 59586737 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-(2-Methoxy-4-nitrophenyl)pyridin-2(1H)-one | HCID 59586767 | — |
Reaction Steps
1.50 g (6.04 mmol) of the product from example 54A are heated overnight in a mixture of 75 ml of dioxane and 75 ml of 4-molar hydrochloric acid. The mixture is then alkalized with sodium carbonate solution. The precipitate is filtered off with suction, washed with water and dried. This affords 1.43 g (96% of theory) of the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08198267B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-b0afc8fabaa44817a8957c151a2ab4ed |
| Source note | uspto-grants-2012_06 |