HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-Ethynyl-1-(1-benzyloxycyclopropyl)-2-methyl-benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | [4-(1-Benzyloxycyclopropyl)-3-methyl-phenylethynyl]-trimethylsilane | HCID 22568919 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Ethynyl-1-(1-benzyloxycyclopropyl)-2-methyl-benzene | HCID 22568852 | — |
Reaction Steps
Using General Procedure E; [4-(1-benzyloxycyclopropyl)-3-methyl-phenylethynyl]-trimethylsilane (Intermediate 75, 300.0 mg, 0.95 mmnols) in methanol (6 mL) was treated with potassium carbonate (120.0 mg, 0.87 mmol) and stirred overnight at ambient temperature. The crude alkyne (185 mg, 79%) was used directly in the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06399774B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-8f9f9fab27334c9da0220eef8a3859b0 |
| Source note | uspto-grants-2002_06 |