1,1'-Carbonyldiimidazole → HCID 59586778, compound

Participants

Reaction Steps

A solution of 850 mg (1.196 mmol) of the compound from example 94A and 387 mg (2.39 mmol) of carbonyldiimidazole in 30 ml of butyronitrile is admixed with 3 mg (0.024 mmol) of 4-dimethylaminopyridine and heated to reflux. After 15 hours, the majority of the solvent is removed on a rotary evaporator. The product is isolated further by means of preparative HPLC with an acetonitrile/water mixture. This affords 605 mg (69% of theory) of the title compound.

Provenance & Evidence