3-Chloro-4-iodoaniline → 3-Allyl-1-(4-amino-2-chlorophenyl)piperidin-2-one

Participants

Reaction Steps

Analogously to the process described under example 93A, 6.00 g (23.7 mmol) of 3-chloro-4-iodoaniline and 4.11 g (29.6 mmol) of the compound from example 96A are used to obtain 1.57 g (25% of theory) of the title compound. The purification is effected by suction filtration using silica gel with 2:1→1:2 cyclohexane/ethyl acetate as the eluent.

Provenance & Evidence