Tetrabutylammonium Fluoride → HCID 59586749, compound

Participants

Reaction Steps

A solution of 8.88 g (11.3 mmol) of the product from example 73A in 225 ml of THF is admixed with 6.95 g (26.6 mmol) of a 1 molar solution of tetrabutylammonium fluoride in THF. The mixture is stirred at RT for 45 min. Then it is freed of the solvent and the residue is purified by chromatography on silica gel (40:1→10:1 dichloromethane/methanol). This affords 5.24 g (80% of theory) of the desired product.

Provenance & Evidence