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HRID2185425

反应详情

EQUATION

反应方程式

HRID 2185425 的结构方程式

REACTANTS

反应物

1
结构：COC(=O)[C@@H]1C[C@@H](C#N)CN1C(=O)OC(C)(C)C
HCID17998966

1-tert-Butyl 2-methyl (2S,4R)-4-cyanopyrrolidine-1,2-dicarboxylate

C12H18N2O4

PRODUCTS

生成物

1
结构：COC(=O)[C@@H]1C[C@@H](CN)CN1C(=O)OC(C)(C)C
HCID54100113

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Ni]
催化剂HCID935

Nickel

Ni

结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A mixture of N-tert-butoxycarbonyl-trans-4-cyano-L-proline methyl ester (A, 197 mg) and Raney-Ni (100 mg) in ethanol (6 mL) was stirred at room temperature for 21 hr under hydrogen. The catalysts were removed by filtration and washed with ethanol. The filtrate was evaporated in vacuo to give the title compound (204 mg).

WORKUP

后处理

  1. customThe catalysts were removed by filtration
  2. washwashed with ethanol
  3. customThe filtrate was evaporated in vacuo