HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-((Benzyloxy)carbonyl)-1-((tert-butoxy)carbonyl)piperazine-2-carboxylic acid → (1-tert-Butoxycarbonyl-4-Benzyloxycarbonylpiperazin-2-ylcarbonyl)-trans-4-((R)-2-Hydroxy-4-Phenylbutyrylamino)-L-Proline 3-Quinolylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-((Benzyloxy)carbonyl)-1-((tert-butoxy)carbonyl)piperazine-2-carboxylic acid | HCID 2756778 | — |
| Reactant | N-tert-Butoxycarbonyl-trans-4-(N-tert-Butoxycarbonylamino)-L-Prolyl-trans-4-((R)-2-Hydroxy-4-Phenylbutyrylamino)-L-Proline 3-Quinolylamide | HCID 21341547 | — |
| Reactant | trans-4-((R)-2-Hydroxy-4-Phenylbutrylamino)-L-Proline 3-Quinolylamide | HCID 59895122 | — |
| Product | (1-tert-Butoxycarbonyl-4-Benzyloxycarbonylpiperazin-2-ylcarbonyl)-trans-4-((R)-2-Hydroxy-4-Phenylbutyrylamino)-L-Proline 3-Quinolylamide | HCID 21341445 | — |
Reaction Steps
trans-4-((R)-2-hydroxy-4-phenybutyrylamino)-L-proline 3-quinolylamide (Compound D101 (H), 272 mg) and 1-tert-butoxycarbonyl-4-benzyloxycarbonylpiperazine-2-ylcarboxylic acid (A, 237 mg) were coupled using the same procedure of Compound D101 (P) to afford the title compound (171 mg) as a colorless glassy solid: mass spectrum (FAB+) m/e 765 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06399629B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-d631619bafde40f09ef877ec7673ff3f |
| Source note | uspto-grants-2002_06 |