6-chloro-N-(4-propan-2-ylphenyl)pyridine-3-carboxamide → N-(4-isopropylphenyl)-6-methoxypyridine-3-carboxamide

Participants

Reaction Conditions

Reaction Steps

N-(4-Isopropylphenyl)-6-chloropyridine-3-carboxamide (1.00 g) was dissolved in THF (10 mL) and sodium methoxide (0.21 g) was added. The mixture was stirred at 50° C. for one day. After cooling, the reaction mixture was partitioned between water and ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated and the residue was purified by silica gel column chromatography to give N-(4-isopropylphenyl)-6-methoxypyridine-3-carboxamide (0.76 g).

Provenance & Evidence