Sodium Hydroxide → HCID 22458538, compound

Participants

Reaction Steps

A solution of ethyl 6-benzylquinoline-3-carboxylate (C, 1.85 g) and 1 N sodium hydroxide solution (7 mL) in ethanol (10 mL) was refluxed for 1.5 hr. After the solvents were removed in vacuo, the residue was diluted with water and washed with ethyl ether. The aqueous layer was acidified with 1 N hydrochloric acid, and the precipitate was collected by filtration to afford the title compound (1.10 g) as a pale yellow powder: mp 203-205° C.; 1H NMR (400 MHz, CD3OD) δ 4.22 (s, 2H), 7.10-7.38 (m, 5H), 7.62-7.85 (m, 2H), 8.03 (d, J=8.6 Hz, 1H), 8.89 (s, 1H), and 9.33 (d, J=1.9 Hz, 1H).

Provenance & Evidence