Hydrochloric Acid → HCID 70177927, compound

Participants

Reaction Steps

A solution of 4 N hydrochloric acid in 1,4-dioxane (6 mL) was added to a solution of 1-[trans-4-(N-tert-butoxycarbonylglycylamino)-N-tert-butoxycarbonyl-L-prolyl]-4-(4-chlorophenyl)piperazine (A, 210 mg) in 1,4-dioxane (6 mL) at room temperature. After stirring at room temperature for 50 min, the reaction mixture was evaporated in vacuo. The residue was washed with ether to give the titled compound (106 mg) as a white powder: 1H NMR (400 MHz, D2O) δ 2.48 (quintet, J=7.3 Hz, 1H), 2.64 (m, 1H), 3.48 (m, 5H), 3.81-3.98 (m, 5H), 3.87 (s, 2H), 4.61 (m, 1H), 5.08 (t, J=8.3 Hz, 1H), 7.32 (d, J=9.0 Hz, 2H), and 7.50 (d, J=9.0 Hz, 2H); mass spectrum (El+) m/e 365 (M).

Provenance & Evidence