Hydrochloric Acid → HCID 70177874, compound

Participants

Reaction Steps

A solution of 4 N hydrochloric acid in 1,4-dioxane (2.5 mL) was added to a solution of 1-[trans-4-(N-tert-butoxycarbonylglycylamino)-N-tert-butoxycarbonyl-L-prolyl]-4-(4-fluorophenyl)piperazine (A, 83 mg) in 1,4-dioxane (2.5 mL) at room temperature. After stirring at room temperature for 30 min, the reaction mixture was evaporated in vacuo. The residue was washed with ether to give the titled compound (43 mg) as a white powder: 1H NMR (400 MHz, D2O) δ 2.51 (m, 1H), 2.63 (m, 1H), 3.48 (dd, J=4.4, 12 Hz, 1H), 3.57 (m, 4H), 3.82 (m, 1H), 3.85 (s, 2H), 3.93 (br s, 3H), 4.02 (m, 1H), 4.60 (br t, 1H), 5.08 (t, J=8.30 Hz, 1H), 7.28 (t, J=8.5 Hz, 2H), and 7.46 (m, 2H); mass spectrum (EI+) ine 349 (M).

Provenance & Evidence