Water → HCID 59895115, compound

Participants

Reaction Steps

Lithium aluminum hydride (1.04 g) was added to a solution of (3R)-1-benzyl-3-phenethylpiperazine-2,5-dione (B, 1.68 g) in tetrahydrofuran (60 mL) at 0° C. After stirring at room temperature for 18 hr, anhydrous sodium sulfate and then water were added at 0° C. The insoluble materials were removed by filtration. The resulting mixture was concentrated in vacuo and then partitioned between chloroform and saturated sodium hydrogen carbonate. The organic layer was dried over anhydrous sodium sulfate and concentrated in vacuo to give the titled compound (1.58 g) as an orange oil, which was used in the next reaction without further purification.

Provenance & Evidence