Hydrochloric Acid → HCID 70177127, compound

Participants

Reaction Steps

A solution of 4 N hydrochloric acid in 1,4-dioxane (5 mL) was added to a solution of (2R)-4-Benzyl-1-[trans-4-(N-tert-butoxycarbonylglycylamino)-N-tert-butoxycarbonyl-D-Prolyl]-2-Phenethylpiperazine (D, 161 mg) in 1,4-dioxane (5 mL) at room temperature. After stirring at room temperature for 20 min, the reaction mixture was concentrated in vacua. The residue was washed with ether to give the titled compound (103 mg) as a beige powder: 1H NMR (400 MHz, D2O) δ 2.00 (m, 2H), 2.19 (m, 1H), 2.41 (quintet, J=7.3 Hz, 1H), 2.58 (m, 1H), 2.71 (m, 2H), 3.18 (t, J=11.7 Hz, 1H), 3.27 (m, 1H), 3.37 (m, 1H), 3.46 (m, 1H), 3.63 (m, 2H), 3.77-3.93 (m, 2H), 3.85 (s, 2H), 4.33-4.49 (m, 3H), 4.58 (m, 1H), 7.24 (t, J=6.8 Hz, 2H), 7.30 (t, J=6.8 Hz, 1H), 7.36 (m, 2H), and 7.48-7.58 (m, 5H).

Provenance & Evidence