Hydrochloric Acid → HCID 70174892, compound

Participants

Reaction Steps

A solution of 4 N hydrochloric acid in 1,4-dioxane (9 mL) was added to a solution of 1-[trans-4-(N-tert-butoxycarbonylglycylamino)-N-tert-butoxycarbonyl-L-Prolyl]-4-(4-benzyloxyphenoxy)piperidine (D, 330 mg) in 1,4-dioxane (9 mL) at room temperature. After stirring at room temperature for 30 min, the reaction mixture was concentrated in vacuo. The residue was washed with ether to give the titled compound (186 mg) as a white powder: 1H NMR (400 MHz, D2O) δ 1.58 (br s, 2H), 1.83 (br s, 2H), 2.25 (m, 1H), 2.43 (m, 1H), 3.20-3.40 (m, 3H), 3.50-3.70 (m, 3H), 3.70 (s, 2H), 4.41 (m, 1H), 4.85 (t, J=8.30 Hz, 1H), 4.93 (s, 2H), 6.85 (s, 4H), and 7.24-7.31 (m, 5H); mass spectrum (E+) m/e 452; IR (KBr) 3438, 3059, 1689, 1651, 1549, 1508, 1228, 1024, 825, 741, and 698 cm−1; Anal. Calcd for C25H32N4O4.2HCl.0.5H2O: C, 56.18; H, 6.60; N, 10.48; Cl, 13.27. Found: C, 56.56; H, 6.61; N, 10.05; Cl, 12.72.

Provenance & Evidence