HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Chlorothiophenol → (2s,4r)-4-(2-Aminoacetamido)-n-[(1r)-3-methyl-1-[(4-chlorphenylthio)methyl]butyl]-2-pyrrolidinecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Chlorothiophenol | HCID 7815 | — |
| Reactant | tert-Butoxycarbonyl-D-leucine | HCID 637604 | — |
| Reactant | trans-4-(N-tert-butoxycarbonylglycyl)amino-N-tert-butoxycarbonyl-L-proline | HCID 21341559 | — |
| Reactant | trans-4-(N-tert-butoxycarbonylaminomethyl)-N-tert-butoxycarbonyl-D-proline | HCID 53725027 | — |
| Reactant | HCID 178515546 | HCID 178515546 | — |
| Product | (2s,4r)-4-(2-Aminoacetamido)-n-[(1r)-3-methyl-1-[(4-chlorphenylthio)methyl]butyl]-2-pyrrolidinecarboxamide | HCID 57072991 | — |
Reaction Steps
This corpound was prepared as for Compound M48, replacing N-tert-butoxycarbonyl-D-homophenylalaine with N-tert-butoxycarbonyl-D-leucine, 2-hydroxyquinoline with 4-chlorothiophenol and trans-4-(N-tert-butoxycarbonylaminomethyl)-N-tert-butoxycarbonyl-D-proline with trans-4-(N-tert-butoxycarbonylglycyl)amino-N-tert-butoxycarbonyl-L-proline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06399629B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-6bc56d751e104077a6127efe68938c59 |
| Source note | uspto-grants-2002_06 |