Triethylamine → HCID 131723255, compound

Participants

Reaction Conditions

Reaction Steps

The product from (A) (3.8 mmol) was dissolved in dimethylformamide (DMF) (20 mL) and the solution was cooled to 0° C. Methanesulfonyl chloride (14.4 mmol) and triethylamine At3N) (14.4 mmol) were added. The reaction was stirred at 0° C. for 2 hr, quenched with H2O (2×25 mL), saturated NaHCO3 (1×25 mL) and brine (1×25 mL). The organic layer was dried over Na2SO4, filtered and dried to give the title compound (1.2g, 92%) as a white solid: 1H NMR (400 MHz, CDCl3) δ 1.60 (9H, s), 1.91-2.05 (2H, m), 2.77-2.90 (2H, m), 3.68-3.82, 3.12 (3H, s), 3.9-4.05 (1H, m), 4.27-4.4 (2H, m), 4.72-4.82 (1H, m), 7.25-7.48 (5H, m).

Provenance & Evidence