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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2185513Generated: October 29, 2026

2-Aminophenol → (2R,4S)-4-(Aminomethyl)-N-[(5-benzyl-2-benzimidazolyl)methyl]-2-pyrrolidinecarboxamide

https://huagongshe.com/reaction/2185513

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-AminophenolHCID 5801—
ReactantBenzyloxycarbonylglycineHCID 14349—
Reactanttrans-4-(N-tert-butoxycarbonylglycyl)amino-N-tert-butoxycarbonyl-L-prolineHCID 21341559—
Reactant4-Benzylbenzene-1,2-diamineHCID 21822416—
Reactantcis-4-(N-tert-butoxycarbonylaminomethyl)-N-tert-butoxycarbonyl-D-prolineHCID 53725028—
Product(2R,4S)-4-(Aminomethyl)-N-[(5-benzyl-2-benzimidazolyl)methyl]-2-pyrrolidinecarboxamideHCID 57093598—

Reaction Steps

This compound was prepared as in Compound M77, replacing N-(Benzyloxycarbonyl)-D-homophenylalanine with N-(Benzyloxycarbonyl)glycine, 2-aminophenol with 1,2diamino-4-benzylbenzene and trans-4-(N-tert-butoxycarbonylglycyl)amino-N-tert-butoxycarbonyl-L-proline with cis-4-(N-tert-butoxycarbonylaminomethyl)-N-tert-butoxycarbonyl-D-proline.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06399629B1
Source datasetuspto-grants-2002_06
ORD IDord-d6b29a7123c54aed910a855a96542ea2
Source noteuspto-grants-2002_06