HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminophenol → (2R,4S)-4-(Aminomethyl)-N-[(5-phenyloxy-2-benzimidazolyl)methyl]-2-pyrrolidinecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminophenol | HCID 5801 | — |
| Reactant | Benzyloxycarbonylglycine | HCID 14349 | — |
| Reactant | 4-Phenoxybenzene-1,2-diamine | HCID 10655643 | — |
| Reactant | trans-4-(N-tert-butoxycarbonylglycyl)amino-N-tert-butoxycarbonyl-L-proline | HCID 21341559 | — |
| Reactant | trans-4-(N-tert-butoxycarbonylaminomethyl)-N-tert-butoxycarbonyl-D-proline | HCID 53725027 | — |
| Product | (2R,4S)-4-(Aminomethyl)-N-[(5-phenyloxy-2-benzimidazolyl)methyl]-2-pyrrolidinecarboxamide | HCID 70176257 | — |
Reaction Steps
This compound was prepared as in Compound M77, replacing N-(Benzyloxycarbonyl)-D-homophenylalanine with N-(Benzyloxycarbonyl)glycine, 2-aminophenol with 1,2-diamino-4-phenyloxybenzene and trans-4-(N-tert-butoxycarbonylglycyl)amino-N-tert-butoxycarbonyl-L-proline with trans-4-(N-tert-butoxycarbonylaminomethyl)-N-tert-butoxycarbonyl-D-proline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06399629B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-3b8451be9e6949f7a156f5bbe319100b |
| Source note | uspto-grants-2002_06 |