trans-4-(N-tert-butoxycarbonylglycyl)amino-N-tert-butoxycarbonyl-L-proline → HCID 57107438, compound

HRID 2185519Notes

Reaction equation

HRID 2185519 reaction equation
[NH2:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([CH2:12][CH3:13])[CH:6]=2.C(OC([NH:21][CH2:22][C:23]([NH:25][C@H:26]1[CH2:30][N:29](C(OC(C)(C)C)=O)[C@H:28]([C:38](O)=[O:39])[CH2:27]1)=[O:24])=O)(C)(C)C>>[NH2:21][CH2:22][C:23]([NH:25][C@H:26]1[CH2:30][NH:29][C@H:28]([C:38]([NH:1][C:2]2[CH:3]=[N:4][C:5]3[C:10]([CH:11]=2)=[CH:9][CH:8]=[C:7]([CH2:12][CH3:13])[CH:6]=3)=[O:39])[CH2:27]1)=[O:24]

Participants

3

Reactant 2

HCID 21341559trans-4-(N-tert-butoxycarbonylglycyl)amino-N-tert-butoxycarbonyl-L-prolineHCID 22458707HCID 22458707, compound

Product 1

HCID 57107438HCID 57107438, compound

Procedure

3-Amino-7-ethylquinoline was coupled with trans-4-(N-tert-butoxycarbonylglycyl)amino-N-tert-butoxycarbonyl-L-proline and deprotected according to Compound M1.

Sources & evidence

ORD record
ord-40846044ef124903a0a29bd7c5439f7b
Source dataset
uspto-grants-2002_06
Patent number
US06399629B1

Reaction notes

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