Aminomebendazole → HCID 57144122, compound

HRID 2185520Notes

Reaction equation

HRID 2185520 reaction equation
[NH2:1][C:2]1[NH:3][C:4]2[CH:10]=[C:9]([C:11](=O)[C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:8]=[CH:7][C:5]=2[N:6]=1.C(OC([NH:26][CH2:27][C:28]([NH:30][C@H:31]1[CH2:35][N:34](C(OC(C)(C)C)=O)[C@H:33]([C:43](O)=[O:44])[CH2:32]1)=[O:29])=O)(C)(C)C>>[NH2:26][CH2:27][C:28]([NH:30][C@H:31]1[CH2:35][NH:34][C@H:33]([C:43]([NH:1][C:2]2[NH:3][C:4]3[CH:10]=[C:9]([CH2:11][C:12]4[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH:8]=[CH:7][C:5]=3[N:6]=2)=[O:44])[CH2:32]1)=[O:29]

Participants

3

Reactant 2

HCID 40320AminomebendazoleHCID 21341559trans-4-(N-tert-butoxycarbonylglycyl)amino-N-tert-butoxycarbonyl-L-proline

Product 1

HCID 57144122HCID 57144122, compound

Procedure

2-Amino-5-benzoylbenzimidazole(J. Med. Chem., 1984, 27, 914-917) was reduced according to Compounds M73(A,B), coupled with trans-4-(N-tert-butoxycarbonylglycyl)amino-N-tert-butoxycarbonyl-L-proline and deprotected according to Compound M1.

Sources & evidence

ORD record
ord-966190e75f2e4a2b85d6f797dc8b97b5
Source dataset
uspto-grants-2002_06
Patent number
US06399629B1

Reaction notes

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