HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → HCID 22458233, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 63289-53-2 | HCID 11148048 | — |
| Reactant | tert-Butyl 4-(methylamino)piperidine-1-carboxylate | HCID 15380702 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 22458233 | HCID 22458233 | — |
Reaction Steps
The title compound was prepared by the reaction of 4-(N-methylamino)-1-tert-butoxycarbonylpiperidine (prepared by the method described in Example 1, Step A, using methylamine in place of ethylamine) with (4-nitrobenzyl)isocyanate (prepared from phosgene and (4-nitrobenzyl)amine), followed by treatment of the product with 50% TFA in CH2Cl2 to remove the tert-butoxycarbonyl group, affording the title compound. ESI-MS: 293.1 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06399619B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-eaef95b8238b4bea82c4c1f152cee190 |
| Source note | uspto-grants-2002_06 |