4-(n-(n-Benzylcarbamoyl)-n-(prop-1-yl)amino)-piperidine trifluoroacetate → 2-(R)-(3-(S)-(4-(N-(N-Benzylcarbamoyl)-N-(prop-1-yl)amino)piperidin-1-yl)methyl-4-(S)-phenyl-pyrrolidin-1-yl)-2(cyclohexyl)acetic acid

Participants

Role	Name	HCID	Charge
Reactant	4-(n-(n-Benzylcarbamoyl)-n-(prop-1-yl)amino)-piperidine trifluoroacetate	HCID 22458269	—
Reactant	alpha-(R)-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)-cyclohexaneacetic acid 4-methoxybenzyl ester	HCID 53654320	—
Product	2-(R)-(3-(S)-(4-(N-(N-Benzylcarbamoyl)-N-(prop-1-yl)amino)piperidin-1-yl)methyl-4-(S)-phenyl-pyrrolidin-1-yl)-2(cyclohexyl)acetic acid	HCID 21341104	40%

Reaction Steps

The title compound was prepared from 4-(N-(N-benzylcarbamoyl)-N(prop-1-yl)amino)-piperidine trifluoroacetate (19 mg, 0.048 mmol, from Step A) and 2-(R)-(3-(R)-formyl-4-(S)-phenyl-pyrrolidin-1-yl)-2-(cyclohexyl)acetic acid, 4-(methoxy)benzyl ester (14 mg, 0.028 mmol, Aldehyde 5) according to the method described in Example 1, Step C to give 6.4 mg (40%) of the title compound. ESI-MS: 575.4 (M+H); HPLC A: 2.32 min.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06399619B1
Source dataset	uspto-grants-2002_06
ORD ID	ord-a62ace6bf1db44cc87224b269edded4d
Source note	uspto-grants-2002_06