HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-(N-((4-Nitrobenzyl)oxycarbonyl)-N-(prop-1-yl)amino)-piperidine trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4-Nitrobenzyl chloroformate | HCID 78205 | — |
| Reactant | Tert-butyl 4-(propylamino)piperidine-1-carboxylate | HCID 22458258 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(N-((4-Nitrobenzyl)oxycarbonyl)-N-(prop-1-yl)amino)-piperidine trifluoroacetate | HCID 22458250 | — |
Reaction Steps
The title compound was prepared by the reaction of 4-(N-(prop-1-yl)amino)-1-tert-butoxycarbonylpiperidine (from Example 17, Step A) with (4-nitrobenzyl)chloroformate, followed by treatment of the product with 50% TFA in CH2Cl2 to remove the tert-butoxycarbonyl group, affording the title compound. ESI-MS: 322.2 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06399619B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-bf50bf7bc7754f3ebba738292e7113fe |
| Source note | uspto-grants-2002_06 |