4-(N-((4-Nitrobenzyl)oxycarbonyl)-N-(prop-1-yl)amino)-piperidine trifluoroacetate → 2-(R)-(3-(S)-(4-(N-((4-Nitrobenzyl)oxycarbonyl)-N-(prop-1-yl)amino)-piperidin-1-yl)methyl-4-(S)-phenyl-pyrrolidin-1-yl)-2-(cyclohexyl)acetic acid

Participants

Reaction Steps

The title compound was prepared from 4-(N-((4-nitrobenzyl)oxycarbonyl)-N-(prop-1-yl)amino)-piperidine trifluoroacetate (21 mg, 0.048 mmol, from Step A) and 2-(R)-(3-(R)-formyl-4-(S)-phenyl-pyrrolidin-1-yl)-2-(cyclohexyl)acetic acid, 4-(methoxy)benzyl ester (14 mg, 0.028 mmol, Aldehyde 5) according to the method described in Example 1, Step C to give 15 mg (89%) of the title compound. ESI-MS: 621.4 (M+H); HPLC A: 2.61 min.

Provenance & Evidence